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Welcome to our new high content library, redesigned with a new search interface, keywords and links to the articles in pubmed or the online journal (note a subscription to the journal maybe needed to download certain articles that are not open access). You as users have certainly been busy publishing on a wide variety of topics. Not in the high-content 450? Let us know about your article and you could win a prize, or be eligible for our "Cellome Award".

2010

Alejandro EU, Kalynyak TB, Taghizadeh F, Gwiazda KS, Rawstron EK, Jacob KJ et al.: Acute Insulin Signaling in Pancreatic Beta-Cells Is Mediated by Multiple Raf-1 Dependent Pathways. Endocrinology 2010, 151: 502-512.

Alvarez-Fernandez M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ et al.: Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. EMBO Rep 2010, 11: 452-458.

Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M et al.: Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat Biotech 2010, 28: 256-263.

Borikova AL, Dibble CF, Sciaky N, Welch CM, Abell AN, Bencharit S et al.: Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype. J Biol Chem 2010, 285: 11760-11764.

Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE et al.: AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity. Cancer Res 2010, 70: 288-298.

Coppa JP, Patil CK, Rodier F, Krtolica A, Beausjour CM, Parrinello S et al.: A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen. PLoS ONE 2010, 5: e9188.

Cuvelier GDE, Kariminia A, Fujii H, Aslanian S, Wall D, Goldman F et al.: Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Group's Study, ASCT0031. Bone Marrow Transplant 2010.

Garrey JL, Lee YY, Au HHT, Bushell M, Jan E: Host and Viral Translational Mechanisms during Cricket Paralysis Virus Infection. J Virol 2010, 84: 1124-1138.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B et al.: A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo. Mol Cancer Ther 2010, 9: 1136-1146.

Jani JP, Arcari J, Bernardo V, Bhattacharya SK, Briere D, Cohen BD et al.: PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy. Mol Cancer Ther 2010, 9: 883-894.

Krishnadas DK, Ahn JS, Han J, Kumar R, Agrawal B: Immunomodulation by hepatitis C virus-derived proteins: targeting human dendritic cells by multiple mechanisms. Int Immunol 2010, 22: 491-502.

Kummel A, Gubler H, Gehin P, Beibel M, Gabriel D, Parker CN: Integration of Multiple Readouts into the Z' Factor for Assay Quality Assessment. J Biomol Screen 2010, 15: 95-101.

Larsson DE, Wickstrom Mali, Hassan Sadi, Oberg Kjel, Granberg Dan: The Cytotoxic Agents NSC-95397, Brefeldin A, Bortezomib and Sanguinarine Induce Apoptosis in Neuroendocrine Tumors In Vitro. Anticancer Res 2010, 30: 149-156.

Lazo JS, Reese CE, Vogt A, Vollmer LL, Kitchens CA, Gunther E et al.: Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C1 and A1. J Pharmacol Exp Ther 2010, 332: 906-911.

Leuchowius KJ, Jarvius M, Wickstrom M, Rickardson L, Landegren U, Larsson R et al.: High Content Screening for Inhibitors of Protein Interactions and Post-translational Modifications in Primary Cells by Proximity Ligation. Mol Cell Proteomics 2010, 9: 178-183.

Levina V, Marrangoni A, Wang T, Parikh S, Su Y, Herberman R et al.: Elimination of Human Lung Cancer Stem Cells through Targeting of the Stem Cell Factor-c-kit Autocrine Signaling Loop. Cancer Res 2010, 70: 338-346.

Lie M, Grover M, Whitlon D: Accelerated Neurite Growth from Spiral Ganglion Neurons Exposed to the Rho Kinase Inhibitor H-1152. Neuroscience 2010.

Lodge AP, Langmead CJ, Daniel G, Anderson GW, Werry TD: Performance of Mouse Neural Stem Cells as a Screening Reagent: Characterization of PAC1 Activity in Medium-Throughput Functional Assays. J Biomol Screen 2010, 15: 159-168.

Macurek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH: Wip1 phosphatase is associated with chromatin and dephosphorylates [gamma]H2AX to promote checkpoint inhibition. Oncogene 2010, 29: 2281-2291.

Mallon R, Hollander I, Feldberg L, Lucas J, Soloveva V, Venkatesan A et al.: Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor. Mol Cancer Ther 2010, 9: 976-984.

McNeish J, Roach M, Hambor J, Mather RJ, Weibley L, Lazzaro J et al.: High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of {alpha}-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors. J Biol Chem 2010, 285: 17209-17217.

Metwalli NS, Benatar M, Nair G, Usher S, Hu X, Carew JD: Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in Amyotrophic Lateral Sclerosis. Brain Res 2010.

Ozaki Yi, Uda S, Saito TH, Chung J, Kubota H, Kuroda S: A Quantitative Image Cytometry Technique for Time Series or Population Analyses of Signaling Networks. PLoS ONE 2010, 5: e9955.

Pennucci J, Swanson S, Kaliyaperumal A, Gupta S: Multiplexed Evaluation of a Cell-Based Assay for the Detection of Antidrug Neutralizing Antibodies to Panitumumab in Human Serum Using Automated Fluorescent Microscopy. J Biomol Screen 2010, 1087057110370893.

Radio NM, Freudenrich TM, Robinette BL, Crofton KM, Mundy WR: Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis. Neurotoxicol Teratol 2010, 32: 25-35.

Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N et al.: Correction of the {Delta}Phe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine. Mol Pharmacol 2010, 77: 922-930.

Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR: Pseudopodial Actin Dynamics Control Epithelial-Mesenchymal Transition in Metastatic Cancer Cells. Cancer Res 2010, 70: 3780-3790.

Shi J, Bezabhie R, Szkudlinska A: Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies. Mutagenesis 2010, 25: 33-40.

Usher LC, Johnstone A, Erturk A, Hu Y, Strikis D, Wanner IB et al.: A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration. J Neurosci 2010, 30: 4693-4706.

Wright KT, Griffiths GJ, Johnson WEB: A Comparison of High-Content Screening versus Manual Analysis to Assay the Effects of Mesenchymal Stem Cell-Conditioned Medium on Neurite Outgrowth In Vitro. J Biomol Screen 2010, 15: 576-582.

Yan X, Zhou T, Tao Y, Wang Q, Liu P, Liu C: Salvianolic acid B attenuates hepatocyte apoptosis by regulating mediators in death receptor and mitochondrial pathways. Exp Biol Med 2010, 235: 623-632.

2009

13th International Symposium on Neural Regeneration (ISNR). Neurorehabil Neural Repair 2009, 23: 954-1000.

Albert BJ, McPherson PA, O'Brien K, Czaicki NL, DeStefino V, Osman S et al.: Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells. Mol Cancer Ther 2009, 8: 2308-2318.

Alexander L, Zhang S, McAuliffe B, Connors D, Zhou N, Wang T et al.: Inhibition of Envelope-Mediated CD4+-T-Cell Depletion by Human Immunodeficiency Virus Attachment Inhibitors. Antimicrob Agents Chemother 2009, 53: 4726-4732.

Bao L, Gorin MA, Zhang M, Ventura AC, Pomerantz WC, Merajver SD et al.: Preclinical Development of a Bifunctional Cancer Cell Homing, PKC{varepsilon} Inhibitory Peptide for the Treatment of Head and Neck Cancer. Cancer Res 2009, 69: 5829-5834.

Bao R, Lai CJ, Wang DG, Qu H, Yin L, Zifcak B et al.: Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer. Mol Cancer Ther 2009, 8: 3296-3306.

Benbow JW, Andrews KA, Aubrecht J, Beebe D, Boyer D, Doran S et al.: Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes. Bioorg Med Chem Lett 2009, 19: 2220-2223.

Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA: SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes Dev 2009, 23: 2484-2489.

Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego-Mendoza MM, Allaire N, Simon K et al.: Identification And Characterization Of Mefloquine Efficacy Against JC Virus In Vitro. Antimicrob Agents Chemother 2009, 53: 1840-1849.

Byrne F, prina-mello a, Whelan A, Mohamed BM, Davies A, Gun'ko YK et al.: High content analysis of the biocompatibility of nickel nanowires. Journal of Magnetism and Magnetic Materials 2009, 321: 1341-1345.

Carter CA, Hamm JT: Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells. Toxicology 2009, 261: 89-102.

Chan EYW, Longatti A, McKnight NC, Tooze SA: Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism. Mol Cell Biol 2009, 29: 157-171.

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF et al.: KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA. PLoS Pathogens 2009, 5: e1000324.

Cheng SM, Li JCB, Lin SS, Lee DCW, Liu L, Chen Z et al.: HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFNg signaling. Blood 2009, 113: 5192-5201.

Doumanis J, Wada K, Kino Y, Moore AW, Nukina N: RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation. PLoS ONE 2009, 4: e7275.

Draghetti C, Salvat C, Zanoguera F, Curchod ML, Vignaud C, Peixoto H et al.: Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator {alpha}B-crystallin. J Biol Chem 2009, 284: 32053-32065.

Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB et al.: Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714. Toxicol Sci 2009, 108: 492-500.

Gao Y, Fotovati A, Lee C, Wang M, Cote G, Guns E et al.: Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase. Mol Cancer Ther 2009, 8: 3276-3284.

Gasparri F, Wang N, Skog S, Galvani A, Eriksson S: Thymidine kinase 1 expression defines an activated G1 state of the cell cycle as revealed with site-specific antibodies and ArrayScan assays. Eur J Cell Biol 2009, 88: 779-785.

Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM et al.: eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival. Cancer Res 2009, 69: 3866-3873.

Gwiazda KS, Yang TL, Lin Y, Johnson JD: Effectsof Palmitateon ERand Cytosolic CA2+ Homeostasisin b-CELLS. Am J Physiol Endocrinol Metab 2009, 296: e690-e701.

Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC et al.: Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J Biol Chem 2009, 284: 13109-13201.

Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K et al.: In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models. Clin Cancer Res 2009, 15: 4649-4664.

Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S et al.: Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas. Mol Cancer Ther 2009, 8: 3024-3035.

Janssen A, Kops GJPL, Medema RH: Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. PNAS 2009, 106: 19108-19113.

Jorgensen C, Sherman A, Chen GI, Pasculescu A, Poliakov A, Hsiung M et al.: Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells. Science 2009, 326: 1502-1509.

Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF et al.: Pomegranate Fruit Extract Impairs Invasion and Motility in Human Breast Cancer. Integr Cancer Ther 2009, 8: 242-253.

Le MTN, Xie H, Zhou B, Chia PH, Rizk P, Um M et al.: MicroRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets. Mol Cell Biol 2009, 29: 5290-5305.

Levina V, Nolen BM, Marrangoni AM, Cheng P, Marks JR, Szczepanski MJ et al.: Role of Eotaxin-1 Signaling in Ovarian Cancer. Clin Cancer Res 2009, 15: 2647-2656.

Levina VV, Nolen B, Su Y, Godwin AK, Fishman D, Liu J et al.: Biological Significance of Prolactin in Gynecologic Cancers 298. Cancer Res 2009, 69: 5226-5233.

Luciani DS, Gwiazda KS, Yang TL, Kalynyak TB, Bychkivska Y, Frey MHZ et al.: Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and b-Cell Death. Diabetes 2009, 58: 422-432.

MacGillavry HD, Stam FJ, Sassen MM, Kegel L, Hendriks WTJ, Verhaagen J et al.: NFIL3 and cAMP Response Element-Binding Protein Form a Transcriptional Feedforward Loop that Controls Neuronal Regeneration-Associated Gene Expression. J Neurosci 2009, 29: 15542-15550.

McManus KJ, Barrett IJ, Nouhi Y, Hieter P: Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. PNAS 2009, 106: 3276-3281.

Mohamed BM, Feighery C, Williams Y, Davies A, Kelleher D, Volkov Y et al.: The use of Cellomics to study enterocyte cytoskeletal proteins in coeliac disease patients. Central European Journal of Biology 2009, 3: 258-267.

Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A et al.: Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ 2009, 16: 449-464.

Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, Lemmon VP et al.: KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science 2009, 326: 298-301.

Muniz-Medina VM, Jones S, Maglich JM, Galardi C, Hollingsworth RE, Kazmierski WM et al.: The Relative Activity of "Function Sparing" HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property? Mol Pharmacol 2009, 75: 490-501.

Mutka SC, Yang WQ, Dong SD, Ward SL, Craig DA, Timmermans PBMW et al.: Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo. Cancer Res 2009, 69: 510-517.

Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K et al.: SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood 2009, 113: 846-855.

Pease ME, Zack DJ, Berlinicke C, Bloom K, Cone F, Wang Y et al.: Effect of CNTF on Retinal Ganglion Cell Survival in Experimental Glaucoma. Invest Ophthalmol Vis Sci 2009, 50: 2194-2200.

Peerani R, Onishi K, Mahdavi A, Kumacheva E, Zandstra PW: Manipulation of Signaling Thresholds in Engineered Stem Cell Niches Identifies Design Criteria for Pluripotent Stem Cell Screens. PLoS ONE 2009, 4: e6438.

Pescini Gobert R, Joubert L, Curchod ML, Salvat C, Foucault I, Jorand-Lebrun C et al.: Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits. Mol Cell Biol 2009, 29: 1538-1553.

Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K et al.: Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation: Evidence for an Intracellular Route. J Biol Chem 2009, 284: 28856-28864.

Raaijmakers JA, Tanenbaum ME, Maia AF, Medema RH: RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. J Cell Sci 2009, 122: 2436-2445.

Rogers GC, Rusan NM, Roberts DM, Peifer M, Rogers SL: The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol 2009, 184: 225-239.

Schoolmeesters A, Eklund T, Leake D, Vermeulen A, Smith Q, Force Aldred S et al.: Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells. PLoS ONE 2009, 4: e5605.

Shedden K, Li Q, Liu F, Chang YT, Rosania GR: Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes. Cytometry A 2009, 75: 482-493.
Products: KineticScan

Shimamoto Y, Suzuki M, Mikhailenko SV, Yasuda K, Ishiwata S: Inter-sarcomere coordination in muscle revealed through individual sarcomere response to quick stretch. PNAS 2009, 106: 11954-11959.

Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S et al.: Novel Tight Binding Inhibitory Factor-kB Kinase Inhibitors (IKK-2) Demonstrate Target Specific Anti-inflammatory Activities in Cellular Assays and Following Oral and Local Delivery in an In Vivo Model of Airway Inflammation. J Pharmacol Exp Ther 2009, 330: 377-388.

Stefanovic S, Abboud N, Desilets S, Nury D, Cowan C, Puceat M: Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 2009, 186: 665-673.

Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A et al.: MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1. Mol Endocrinol 2009, 23: 1876-1884.

Tang D, Kang R, Xiao W, Zhang H, Lotze MT, Wang H et al.: Quercetin Prevents Lipopolysaccharide-induced HMGB1 Release and Proinflammatory Function. Am J Respir Cell Mol Biol 2009, preprint: 0.

Thaker NG, Zhang F, McDonald PR, Shun TY, Lewen MD, Pollack IF et al.: Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening. Mol Pharmacol 2009, 76: 1246-1255.

Tian F, Liang PH, Li LY: Inhibition of endothelial progenitor cell differentiation by VEGI. Blood 2009, 113: 5352-5360.
Products: ArrayScan

Tierno MB, Kitchens CA, Petrik B, Graham TH, Wipf P, Xu FL et al.: Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1. J Pharmacol Exp Ther 2009, 328: 715-722.

Trzcinska-Daneluti A, Ly D, Huynh L, Jiang C, Fladd C, Rotin D: High-content functional screen to identify proteins that correct F508del-CFTR function. Mol Cell Proteomics 2009, 8: 780-790.

VanderPorten EC, Taverna P, Hogan JN, Ballinger MD, Flanagan WM, Fucini RV: The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol Cancer Ther 2009, 8: 930-939.

Walton KM, Fisher K, Rubitski D, Marconi M, Meng QJ, Sladek M et al.: Selective Inhibition of Casein Kinase 1 Epsilon Minimally Alters Circadian Clock Period. J Pharmacol Exp Ther 2009, 330: 430-439.

Widenmaier SB, Sampaio AV, Underhill TM, McIntosh CHS: Non-canonical activation of Akt/PKB in beta -cells by the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). J Biol Chem 2009, 284: 10764-10773.

Wu HL, Li YH, Lin YH, Wang R, Li YB, Tie L et al.: Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction. Cardiovasc Res 2009, 81: 148-158.

Xu Y, Li J, Ferguson GD, Mercurio F, Khambatta G, Morrison L et al.: Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood 2009, 114: 338-345.

Yin Y, Cui Q, Gilbert Hy, Yang Y, Yang Z, Berlinicke C et al.: Oncomodulin links inflammation to optic nerve regeneration. PNAS 2009, 106: 19587-19592.

Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JYJ, Berns MW et al.: Double-strand DNA breaks recruit the centromeric histone CENP-A. PNAS 2009, 106: 15762-15767.

Zhang G, Liu X, Farkas AM, Parwani AV, Lathrop KL, Lenzner D et al.: Estrogen Receptor b Functions through Nongenomic Mechanisms in Lung Cancer Cells. Mol Endocrinol 2009, 23: 146-156.

Zou H, Thomas SM, Yan ZW, Grandis JR, Vogt A, Li LY: Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J 2009, 23: 425-432.

2008

Aberg M, Wickstrom M, Siegbahn A: Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. Thromb Res 2008, 122: 191-202.

Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ: Application of a High-Content Multiparameter Cytotoxicity Assay to Prioritize Compounds Based on Toxicity Potential in Humans. J Biomol Screen 2008, 13: 527-537.

Alejandro EU, Johnson JD: Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic b-Cell Apoptosis. J Biol Chem 2008, 283: 2407-2417.

Arrell DK, Niederlander NJ, Faustino RS, Behfar A, Terzic A: Cardioinductive Network Guiding Stem Cell Differentiation Revealed by Proteomic Cartography of Tumor Necrosis Factor a-Primed Endodermal Secretome. Stem Cells 2008, 26: 387-400.

Barnard R, Barnard A, Salmon G, Liu W, Sreckovic S: Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptor. Cytometry A 2008, 73: 299-304.

Basu P, Ghosh RN, Grove LE, Klei L, Barchowsky A: Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic Acid (roxarsone). Environ Health Perspect 2008, 116: 520-523.

Bauwens C, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M et al.: Control of Human Embryonic Stem Cell Colony and Aggregate Size Heterogeneity Influences Differentiation Trajectories. Stem Cells 2008, 26: 2300-2310.

Bednarek R, Boncela J, Smolarczyk K, Cierniewska-Cieslak A, Wyroba E, Cierniewski CS: Ku80 as a Novel Receptor for Thymosin 4 That Mediates Its Intracellular Activity Different from G-actin Sequestering. J Biol Chem 2008, 283: 1534-1544.

Beith JL, Alejandro EU, Johnson JD: Insulin Stimulates Primary b-Cell Proliferation via Raf-1 Kinase. Endocrinology 2008, 149: 2251-2260.

Breier JM, Radio NM, Mundy WR, Shafer TJ: Development of a High-Throughput Screening Assay for Chemical Effects on Proliferation and Viability of Immortalized Human Neural Progenitor Cells. Toxicol Sci 2008, 105: 119-133.

Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF et al.: Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1. Cancer Res 2008, 68: 7428-7438.

Chen Y, Wei T, Yan L, Lawrence F, Qian H-R, Burkholder TP et al.: Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model. BMC Genomics 2008, 9: 264.

Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA: Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev 2008, 22: 746-755.

Cummings J, Hodgkinson C, Odedra R, Sini P, Heaton SP, Mundt KE et al.: Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity. Mol Cancer Ther 2008, 7: 455-463.

Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M et al.: RNA-binding Protein TLS Is a Major Nuclear Aggregate-interacting Protein in Huntingtin Exon 1 with Expanded Polyglutamine-expressing Cells. J Biol Chem 2008, 283: 6489-6500.

Drake PJ, Griffiths GJ, Shaw L, Benson RP, Corfe BM: Application of High-Content Analysis to the Study of Post-Translational Modifications of the Cytoskeleton. J Proteome Res 2008, 8: 28-34.

Du W, Hozumi N, Sakamoto M, Hata Ji, Yamada T: Reconstitution of Schwannian Stroma in Neuroblastomas Using Human Bone Marrow Stromal Cells. Am J Pathol 2008, 173: 1153-1164.

Dykens JA, Jamieson JD, Marroquin LD, Nadanaciva S, Xu JJ, Dunn MC et al.: In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone. Toxicol Sci 2008, 103: 335-345.

Furukawa Y, Kaneko K, Yamanaka K, O'Halloran TV, Nukina N: Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis. J Biol Chem 2008, 283: 24167-24176.

Gasparri F, Sola F, Bandiera T, Moll J, Galvani A (Eds):High-content analysis of kinase activity in cells. In Comb Chem High Throughput Screen 2008, 11: 523-536.

Hall JR, Lee HO, Bunker BD, Dorn ES, Rogers GC, Duronio RJ et al.: Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage. J Biol Chem 2008, 283: 25356-25363.

Harrill JA, Li Z, Wright FA, Radio NM, Mundy WR, Tornero-Velez R et al.: Transcriptional response of rat frontal cortex following acute In Vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. BMC Genomics 2008, 9: 546.

He X, Fang L, Wang J, Yi Y, Zhang S, Xie X: Bryostatin-5 Blocks Stromal Cell-Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors. Cancer Res 2008, 68: 8678-8686.

Hirst J, Sahlender DA, Li S, Lubben NB, Borner GH, Robinson MS: Auxilin depletion causes self-assembly of clathrin into membraneless cages in vivo. Traffic 2008, 9: 1354-1371.

Hang S: Classification of Cell Subpopulations Using Multiple Cellular Parameters from High-Content Imaging Studies. J Biomol Screen 2008, 13: 941-952.

Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H et al.: Carboxypeptidase E mediates palmitate-induced b-cell ER stress and apoptosis. PNAS 2008, 105: 8452-8457.

Johnson MC, Damon IK, Karem KL: A rapid, high-throughput vaccinia virus neutralization assay for testing smallpox vaccine efficacy based on detection of green fluorescent protein. J Virol Methods 2008, 150: 14-20.

LaPan P, Zhang J, Pan J, Hill A, Haney SA: Single cell cytometry of protein function in RNAi treated cells and in native populations. BMC Cell Biol 2008, 9: 43.

Law JH, Habibi G, Hu K, Masoudi H, Wang MYC, Stratford AL et al.: Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival. Cancer Res 2008, 68: 10238-10246.

Lee C, Dhillon J, Wang MYC, Gao Y, Hu K, Park E et al.: Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice. Cancer Res 2008, 68: 8661-8666.

Levina V, Su Y, Nolen B, Liu X, Gordin Y, Lee M et al.: Chemotherapeutic drugs and human tumor cells cytokine network. Int J Cancer 2008, 123: 2031-2040.

Levina V, Marrangoni AM, DeMarco R, Gorelik E, Lokshin AE: Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production. Experimental Cell Research 2008, 314: 1605-1616.

Levina V, Marrangoni AM, DeMarco R, Gorelik E, Lokshin A: Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS ONE 2008, 3: e3077.

Loh SH, Francescut L, Lingor P, Bahr M, Nicotera P: Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Cell Death Differ 2008, 15: 283-298.

Low J, Huang S, Blosser W, Dowless M, Burch J, Neubauer B et al.: High-content imaging characterization of cell cycle therapeutics through in vitro and in vivo subpopulation analysis. Mol Cancer Ther 2008, 7: 2455-2463.

Mattila J, Kallijarvi J, Puig O: RNAi screening for kinases and phosphatases identifies FoxO regulators. PNAS 2008, 105: 14873-14878.

Mundy WR, Robinette B, Radio NM, Freudenrich TM: Protein biomarkers associated with growth and synaptogenesis in a cell culture model of neuronal development. Toxicology 2008, 249: 220-229.

O'Brien C, Cavet G, Pandita A, Hu X, Haydu L, Mohan S et al.: Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer. Cancer Res 2008, 68: 5380-5389.

Purpura KA, George SHL, Dang SM, Choi K, Nagy A, Zandstra PW: Soluble Flt-1 Regulates Flk-1 Activation to Control Hematopoietic and Endothelial Development in an Oxygen-Responsive Manner. Stem Cells 2008, 26: 2832-2842.

Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K et al.: Cell-Based and Biochemical Structure-Activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin. Mol Pharmacol 2008, 73: 718-726.

Radio NM, Mundy WR: Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth. Neurotoxicology 2008, 29: 361-376.Radio NM, Breier JM, Shafer TJ, Mundy WR: Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening. Toxicol Sci 2008, 105: 106-118.

Rogers GC, Rusan NM, Peifer M, Rogers SL: A Multicomponent Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila Cells. Mol Biol Cell 2008, 19: 3163-3178.
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Ross-Macdonald P, de Silva H, Guo Q, Xiao H, Hung CY, Penhallow B et al.: Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther 2008, 7: 3490-3498.

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D et al.: Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. PNAS 2008, 105: 33-38.

Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA et al.: ING2 as a Novel Mediator of Transforming Growth Factor-ß-dependent Responses in Epithelial Cells. J Biol Chem 2008, 283: 13269-13279.

Tay YMS, Tam WL, Ang YS, Gaughwin PM, Yang H, Wang W et al.: MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1. Stem Cells 2008, 26: 17-29.

Trammell MA, Mahoney NM, Agard DA, Vale RD: Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci 2008, 121: 1284-1292.

Varjosalo M, Bjorklund M, Cheng F, Syvanen H, Kivioja T, Kilpinen S et al.: Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 2008, 133: 537-548.

Vogt A, McDonald PR, Tamewitz A, Sikorski RP, Wipf P, Skoko JJ, III et al.: A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther 2008, 7: 330-340.

Wang XH, Xu B, Liu JT, Cui JR: Effect of beta-escin sodium on endothelial cells proliferation, migration and apoptosis. Vascul Pharmacol 2008, 49: 158-165.

Wei SY, Li M, Tang SA, Sun W, Xu B, Cui JR et al.: Induction of apoptosis accompanying with G(1) phase arrest and microtubule disassembly in human hepatoma cells by jaspolide B, a new isomalabaricane-type triterpene. Cancer Lett 2008, 262: 114-122.

Williams G, Wood A, Williams EJ, Gao Y, Mercado ML, Katz A et al.: Ganglioside Inhibition of Neurite Outgrowth Requires Nogo Receptor Function: Identification Of Interaction Sites And Development Of Novel Antagonists. J Biol Chem 2008, 283: 16641-16652.

Wong HK, Bauer PO, Kurosawa M, Goswami A, Washizu C, Machida Y et al.: Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism. Hum Mol Genet 2008, 17: 3223-3235.

Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Abramov AS, Miljan EA et al.: PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 2008, 3: e2455.

Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL et al.: A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis 2008, 13: 413-422.

Xu JJ, Henstock PV, Dunn MC, Smith AR, Chabot JR, de Graaf D: Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury. Toxicol Sci 2008, 105: 97-105.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY et al.: Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol 2008, 4: 59-68.

Zavareh RB, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M et al.: Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function. Cancer Res 2008, 68: 6688-6697.

Zhang Y, Gavriil M, Lucas J, Mandiyan S, Follettie M, Diesl V et al.: IkBa Kinase Inhibitor IKI-1 Conferred Tumor Necrosis Factor a Sensitivity to Pancreatic Cancer Cells and a Xenograft Tumor Model. Cancer Res 2008, 68: 9519-9524.

2007

Achiwa H, Lazo JS: PRL-1 Tyrosine Phosphatase Regulates c-Src Levels, Adherence, and Invasion in Human Lung Cancer Cells. Cancer Res 2007, 67: 643-650.

Agler M, Prack M, Yingjie Z, Kolb J, Nowak K, Ryseck R et al.: A High-Content Glucocorticoid Receptor Translocation Assay for Compound Mechanism-of-Action Evaluation. J Biomol Screen 2007, 12: 1029-1041.

Badura L, Swanson T, Adamowicz W, Adams J, Cianfrogna J, Fisher K et al.: An Inhibitor of Casein Kinase Ie Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions. J Pharmacol Exp Ther 2007, 322: 730-738.

Behfar A, Perez-Terzic C, Faustino RS, Arrell DK, Hodgson DM, Yamada S et al.: Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med 2007, 204: 405-420.

Benanti JA, Cheung SK, Brady MC, Toczyski DP: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nat Cell Biol 2007, 9: 1184-1191.

Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR et al.: Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. PNAS 2007, 104: 10619-10624.

Cheung P, Dennis JW: Mgat5 and Pten interact to regulate cell growth and polarity. Glycobiology 2007, 17: 767-773.

Cheung P, Pawling J, Partridge EA, Sukhu B, Grynpas M, Dennis JW: Metabolic homeostasis and tissue renewal are dependent on ß1,6GlcNAc-branched N-glycans. Glycobiology 2007, 17: 828-837.

Davey RE, Onishi K, Mahdavi A, Zandstra PW: LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. FASEB J 2007, 21: 2020-2032.

Dawes LJ, Angell H, Sleeman M, Reddan JR, Wormstone IM: TGFb isoform dependent Smad2/3 kinetics in human lens epithelial cells: A Cellomics analysis. Experimental Eye Research 2007, 84: 1009-1012.

Diaz D, Scott A, Carmichael P, Shi W, Costales C: Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutation Research 2007, 630: 1-13.

Durr O, Duval F, Nichols A, Lang P, Brodte A, Heyse S et al.: Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay. J Biomol Screen 2007, 12: 1042-1049.

Gasparri F, Ciavolella A, Galvani A: Cell-cycle inhibitor profiling by high-content analysis. 604 edition. Edited by di Fagagna f, Chiocca S, McBlane F, Cavallaro U. Springer; 2007:137-148.

Ghosh RN, Lapets O, Haskins JR: Characteristics and value of directed algorithms in high content screening. Methods Mol Biol 2007, 356: 63-81.

Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, Dougall WC: RANK Overexpression in Transgenic Mice with Mouse Mammary Tumor Virus Promoter-Controlled RANK Increases Proliferation and Impairs Alveolar Differentiation in the Mammary Epithelia and Disrupts Lumen Formation in Cultured Epithelial Acini. Mol Cell Biol 2007, 27: 1442-1454.

Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN et al.: Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest 2007, 117: 2638-2648.

Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J et al.: Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer. Clin Cancer Res 2007, 13: 5745-5755.

Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP et al.: The b-tail domain (bTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood 2007, 109: 3513-3520.

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S: LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J 2007, 26: 313-324.

Joslin EJ, Opresko LK, Wells A, Wiley HS, Lauffenburger DA: EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J Cell Sci 2007, 120: 3688-3699.

Labbe E, Lock L, Letamendia A, Gorska AE, Gryfe R, Gallinger S et al.: Transcriptional Cooperation between the Transforming Growth Factor-ß and Wnt Pathways in Mammary and Intestinal Tumorigenesis. Cancer Res 2007, 67: 75-84.

Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, Lagana A et al.: Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol 2007, 179: 341-356.

Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M et al.: Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 2007, 129: 123-134.

Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ et al.: MIO-M1 Cells and Similar Muller Glial Cell Lines Derived from Adult Human Retina Exhibit Neural Stem Cell Characteristics. Stem Cells 2007, 25: 2033-2043.

Li Y, Pan J, Li JL, Lee JH, Tunkey C, Saraf K et al.: Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Molecular Cancer 2007, 6: 7.

Liu D, McIlvain HB, Fennell M, Dunlop J, Wood A, Zaleska MM et al.: Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells. J Neurosci Methods 2007, 163: 310-320.

Low J, Shuguang H, Dowless M, Blosser W, Vincent T, Davis S et al.: High-Content Imaging Analysis of the Knockdown Effects of Validated siRNAs and Antisense Oligonucleotides. J Biomol Screen 2007, 12: 775-788.

Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW: Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control. PLoS Computational Biology 2007, 3: n/a.

Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A et al.: Complex N-Glycan and Metabolic Control in Tumor Cells. Cancer Res 2007, 67: 9771-9780.

O'Brien P, Haskins JR: In vitro cytotoxicity assessment. Methods Mol Biol 2007, 356:415-25.: 415-425.

Park JY, Amin Arnaout M, Gupta V: A Simple, No-Wash Cell Adhesion-Based High-Throughput Assay for the Discovery of Small-Molecule Regulators of the Integrin CD11b/CD18. J Biomol Screen 2007, 12: 406-417.

Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A et al.: Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J 2007, 26: 4744-4755.

Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D et al.: The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol 2007, 9: 1243-1252.

Rickardson L, Wickstrom M, Larsson R, Lovborg H: Image-Based Screening for the Identification of Novel Proteasome Inhibitors. J Biomol Screen 2007, 12: 203-210.

Rigamonti D, Bolognini D, Mutti C, Zuccato C, Tartari M, Sola F et al.: Loss of Huntingtin Function Complemented by Small Molecules Acting as Repressor Element 1/Neuron Restrictive Silencer Element Silencer Modulators. J Biol Chem 2007, 282: 24554-24562.

Sartore-Bianchi A, Gasparri F, Galvani A, Nici L, Darnowski JW, Barbone D et al.: Bortezomib Inhibits Nuclear Factor-kB Dependent Survival and Has Potent In vivo Activity in Mesothelioma. Clin Cancer Res 2007, 13: 5942-5951.

Shin Y, Fournier JH, Bruckner AM, Madiraju C, Balachandran R, Raccor BS et al.: Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. Tetrahedron 2007, 63: 8537-8562.

Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E et al.: Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy. Breast Cancer Res 2007, 9: R61.

Tao CY, Hoyt J, Yan F: A Support Vector Machine Classifier for Recognizing Mitotic Subphases Using High-Content Screening Data. J Biomol Screen 2007, 12: 490-496.

Tedesco D, Zhang J, Trinh L, Lalehzadeh G, Meisner R, Yamaguchi KD et al.: The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition. Neoplasia 2007, 9: 601-613.

Tian F, Zhu Ch, Zhang Xw, Xie X, Xin Xl, Yi Yh et al.: Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction between Kinase Insert Domain-Containing Receptor (KDR) and avbeta3 Integrin via Binding to the Extracellular Domain of KDR. Mol Pharmacol 2007, 72: 545-552.

Tian F, Grimaldo S, Fugita M, Cutts J, Vujanovic NL, Li LY: The Endothelial Cell-Produced Antiangiogenic Cytokine Vascular Endothelial Growth Inhibitor Induces Dendritic Cell Maturation. J Immunol 2007, 179: 3742-3751.

To K, Zhao Y, Jiang H, Hu K, Wang M, Wu J et al.: The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor. Mol Pharmacol 2007, 72: 641-652.

Van Sant C, Wang G, Anderson MG, Trask OJ, Lesniewski R, Semizarov D: Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway. Mol Cancer Ther 2007, 6: 253-261.

Vogt A, Lazo JS: Discovery of protein kinase phosphatase inhibitors. Methods Mol Biol 2007, 356: 389-400.

Vogt A, Lazo JS: Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases. Methods 2007, 42: 268-277.

Walker E, Ohishi M, Davey RE, Zhang W, Cassar PA, Tanaka TS et al.: Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment. Cell Stem Cell 2007, 1: 71-86.

Wang J, Xie X: Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators. Acta Pharmacol Sin 2007, 28: 1698-1704.

Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW et al.: Structure-activity and high-content imaging analyses of novel tubulysins. Chem Biol Drug Des 2007, 70: 75-86.

Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ: A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci 2007, 120: 45-54.

Wickstrom M, Danielsson K, Rickardson L, Gullbo J, Nygren P, Isaksson A et al.: Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol 2007, 73: 25-33.

Wickstrom M, Johnsen JI, Ponthan F, Segerstrom L, Sveinbjornsson B, Lindskog M et al.: The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo. Mol Cancer Ther 2007, 6: 2409-2417.

Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C et al.: AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis. Clin Cancer Res 2007, 13: 3682-3688.

Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W et al.: Small molecule regulators of autophagy identified by an image-based high-throughput screen. PNAS 2007, 104: 19023-19028.

2006

Barabasz A, Foley B, Otto JC, Scott A, Rice J: The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action. Assay Drug Dev Technol 2006, 4: 153-163.

Bertelsen M: Multiplex analysis of inflammatory signaling pathways using a high-content imaging system. Methods Enzymol 2006, 414: 348-363.

Bjorklund M, Taipale M, Varjosalo M, Saharinen J, Lahdenpera J, Taipale J: Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 2006, 439: 1009-1013.

Buchser WJ, Pardinas JR, Shi Y, Bixby JL, Lemmon VP: 96-well electroporation method for transfection of mammalian central neurons. Biotechniques 2006, 41: 619-624.

Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE et al.: MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity: Relevance To Neuroinflammation In A Transgenic Mouse Model Of Alzheimer Disease. J Biol Chem 2006, 281: 23658-23667.

Davey RE, Zandstra PW: Spatial Organization of Embryonic Stem Cell Responsiveness to Autocrine Gp130 Ligands Reveals an Autoregulatory Stem Cell Niche. Stem Cells 2006, 24: 2538-2548.

Fennell M, Chan H, Wood A: Multiparameter Measurement of Caspase 3 Activation and Apoptotic Cell Death in NT2 Neuronal Precursor Cells Using High-Content Analysis. J Biomol Screen 2006, 11: 296-302.

Foehr ED, Lorente G, Kuo J, Ram R, Nikolich K, Urfer R: Targeting of the Receptor Protein Tyrosine Phosphatase ß with a Monoclonal Antibody Delays Tumor Growth in a Glioblastoma Model. Cancer Res 2006, 66: 2271-2278.

Fowler A, Seifert N, Acker V, Woehrle T, Kilpert C, de Saizieu A: A Nonradioactive High-Throughput/High-Content Assay for Measurement of the Human Serotonin Reuptake Transporter Function In Vitro. J Biomol Screen 2006, 11: 1027-1034.

Fryknas M, Rickardson L, Wickstrom M, Dhar S, Lovborg H, Gullbo J et al.: Phenotype-Based Screening of Mechanistically Annotated Compounds in Combination with Gene Expression and Pathway Analysis Identifies Candidate Drug Targets in a Human Squamous Carcinoma Cell Model. J Biomol Screen 2006, 11: 457-468.

Gasparri F, Cappella P, Galvani A: Multiparametric Cell Cycle Analysis by Automated Microscopy. J Biomol Screen 2006, 11: 586-598.

Giuliano KA, Johnston PA, Gough A, Taylor DL (Eds):Systems cell biology based on high-content screening. In Methods Enzymol 2006, 414: 601-619.

Grove LE, Ghosh RN: Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis. Assay & Drug Development Technologies 2006, 4: 421-442.

Harrison BC, Kim MS, van Rooij E, Plato CF, Papst PJ, Vega RB et al.: Regulation of Cardiac Stress Signaling by Protein Kinase D1. Mol Cell Biol 2006, 26: 3875-3888.

Hassan SB, Lovborg H, Lindhagen E, Karlsson MO, Larsson R: CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. Anticancer Res 2006, 26: 4431-4436.

Imre G, Gekeler V, Leja A, Beckers T, Boehm M: Histone Deacetylase Inhibitors Suppress the Inducibility of Nuclear Factor-kß by Tumor Necrosis Factor-a Receptor-1 Down-regulation. Cancer Res 2006, 66: 5409-5418.

Inglefield JR, Larson CJ, Gibson SJ, Lebrec H, Miller RL: Apoptotic Responses in Squamous Carcinoma and Epithelial Cells to Small-Molecule Toll-like Receptor Agonists Evaluated with Automated Cytometry. J Biomol Screen 2006, 11: 575-585.

Lagana A, Goetz JG, Cheung P, Raz A, Dennis JW, Nabi IR: Galectin Binding to Mgat5-Modified N-Glycans Regulates Fibronectin Matrix Remodeling in Tumor Cells. Mol Cell Biol 2006, 26: 3181-3193.

Lamian V, Rich A, Ma Z, Li J, Seethala R, Gordon D et al.: Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis. Mol Pharmacol 2006, 69: 109-118.

Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J et al.: Antagonist-Induced, Activation Function-2-Independent Estrogen Receptor a Phosphorylation. Mol Endocrinol 2006, 20: 516-533.

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D et al.: Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5. Cancer Res 2006, 66: 11851-11858.

McIlvain HB, Baudy A, Sullivan K, Liu D, Pong K, Fennell M et al.: Pituitary adenylate cyclase-activating peptide (PACAP) induces differentiation in the neuronal F11 cell line through a PKA-dependent pathway . Brain Research 2006, 1077: 16-23.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G et al.: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 2006, 124: 1283-1298.

Morelli JK, Buehrle M, Pognan F, Barone LR, Fieles W, Ciaccio PJ: Validation of an in vitro screen for phospholipidosis using a high-content biology platform. Cell Biology and Toxicology 2006, 22: 15-27.

Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A et al.: The Structure of the Lingo-1 Ectodomain, a Module Implicated in Central Nervous System Repair Inhibition. J Biol Chem 2006, 281: 36378-36390.

Nagaoka M, Koshimizu U, Yuasa S, Hattori F, Chen H, Tanaka T et al.: E-Cadherin-Coated Plates Maintain Pluripotent ES Cells without Colony Formation. PLoS ONE 2006, 1: e15.

O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR et al.: High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol 2006, 80: 580-604.

Oliva AA, Jr., Atkins CM, Copenagle L, Banker GA: Activated c-Jun N-Terminal Kinase Is Required for Axon Formation. J Neurosci 2006, 26: 9462-9470.

Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL et al.: Chemical Enhancers of Cytokine Signaling that Suppress Microfilament Turnover and Tumor Cell Growth. Cancer Res 2006, 66: 3558-3566.

Qian MD, Zhang J, Tan XY, Wood A, Gill D, Cho S: Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities. J Neurosci 2006, 26: 9394-9403.

Sanjuan MA, Rao N, Lai KT, Gu Y, Sun S, Fuchs A et al.: CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol 2006, 172: 1057-1068.

Schmidt M, Hofmann HP, Sanders K, Sczakiel G, Beckers TL, Gekeler V: Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells. Mol Cancer Ther 2006, 5: 809-817.

Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L et al.: PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity. Clin Cancer Res 2006, 12: 4080-4089.

Trask OJ, Jr., Baker A, Williams RG, Nickischer D, Kandasamy R, Laethem C et al.: Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol 2006, 414:419-39.: 419-439.

Vidali L, Chen F, Cicchetti G, Ohta Y, Kwiatkowski DJ: Rac1-null Mouse Embryonic Fibroblasts Are Motile and Respond to Platelet-derived Growth Factor. Mol Biol Cell 2006, 17: 2377-2390.

Volkov Y, Long A, Freeley M, Golden-Mason L, O'Farrelly C, Murphy A et al.: The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Gastroenterology 2006, 130: 482-492.

Wheeler RT, Wheeler RT, Fink GR, Fink GR: A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog 2006, 2: e35.

Williams RG, Kandasamy R, Nickischer D, Trask OJ, Jr., Laethem C, Johnston PA et al.: Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors. Methods Enzymol 2006, 414: 364-389.

Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS: Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des 2006, 67: 66-73.

Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD et al.: Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Molecular Systems Biology 2006, 2: 54.

Yan P, Nanamori M, Sun M, Zhou C, Cheng N, Li N et al.: The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding. J Immunol 2006, 177: 7050-7058.

2005

Bertelsen M, Sanfridson A: Inflammatory pathway analysis using a high content screening platform. Assay & Drug Development Technologies 2005, 3: 261-271.

Borchert KM, Galvin RJ, Frolik CA, Hale LV, Halladay DL, Gonyier RJ et al.: High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells. Assay & Drug Development Technologies 2005, 3: 133-141.

Bova MP, Tam D, McMahon G, Mattson MN: Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells. Toxicology Letters 2005, 155: 41-50.

Doshna CM, Shen AC, Gebhard DF, Brees DJ, Somps CJ: Investigating Markers of DNA Oxidation, Lipid Peroxidation and Stress Response in Human Lens Epithelial Cell Lines. Invest Ophthalmol Vis Sci 2005, 46: 3850.

Ghosh RN, DeBiasio R, Hudson CC, Ramer ER, Cowan CL, Oakley RH: Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor(R)Technology. J Biomol Screen 2005, 10: 476-484.

Giuliano KA, Cheung WS, Curran DP, Day BW, Kassick AJ, Lazo JS et al.: Systems cell biology knowledge created from high content screening. Assay & Drug Development Technologies 2005, 3: 501-514.

Grace MJ, Lee S, Bradshaw S, Chapman J, Spond J, Cox S et al.: Site of Pegylation and Polyethylene Glycol Molecule Size Attenuate Interferon-a Antiviral and Antiproliferative Activities through the JAK/STAT Signaling Pathway. J Biol Chem 2005, 280: 6327-6336.

Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M et al.: Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005, 11: 90-94.
Products: ArrayScan receptor internalization

Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE et al.: Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation. Cancer Res 2005, 65: 9294-9303.

Huang S, Zhou H, Katzmann D, Hochstrasser M, Atanasova E, Zhang Z: Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. PNAS 2005, 102: 13410-13415.

Ilyin SE, Horowitz D, Belkowski SM, Xin H, Eckardt AJ, Darrow AL et al.: Integrated expressional analysis: application to the drug discovery process. Methods 2005, 37: 280-288.

Kerrison JB, Lewis RN, Otteson DC, Zack DJ: Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells. Molecular Vision 2005, 11: 208-215.

Kerrison JB, Duh EJ, Yu Y, Otteson DC, Zack DJ: A System for Inducible Gene Expression in Retinal Ganglion Cells. Invest Ophthalmol Vis Sci 2005, 46: 2932-2939.

Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, Cheung P et al.: Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. PNAS 2005, 102: 1098-1103.

Lotharius J, Falsig J, van Beek J, Payne S, Dringen R, Brundin P et al.: Progressive Degeneration of Human Mesencephalic Neuron-Derived Cells Triggered by Dopamine-Dependent Oxidative Stress Is Dependent on the Mixed-Lineage Kinase Pathway. J Neurosci 2005, 25: 6329-6342.

Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G et al.: Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry 2005, 44: 15053-15063.

Panelli MC, Wang E, Marincola FM (Eds):The Pathway to Biomarker Discovery: Carbonic Anhydrase IX and the Prediction of Immune Responsiveness. In Clin Cancer Res 2005, 11: 3601-3603.

Pece-Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo GM, Dejana E et al.: Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor b1 with Higher Affinity Receptors and an Activated Alk1 Pathway. J Biol Chem 2005, 280: 27800-27808.

Rane MJ, Gozal D, Butt W, Gozal E, Pierce WM, Jr., Guo SZ et al.: g-Amino Butyric Acid Type B Receptors Stimulate Neutrophil Chemotaxis during Ischemia-Reperfusion. J Immunol 2005, 174: 7242-7249.

Saito S, Honma K, Kita-Matsuo H, Ochiya T, Kato K: Gene expression profiling of cerebellar development with high-throughput functional analysis. Physiol Genomics 2005, 22: 8-13.

Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA et al.: Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J Cell Biol 2005, 169: 139-149.

Tian Q, Li J, Xie X, Sun M, Sang H, Zhou C et al.: Stereospecific Induction of Nuclear Factor-kB Activation by Isochamaejasmin. Mol Pharmacol 2005, 68: 1534-1542.

Vasudevan C, Fursov N, Maunder P, Cong M, Federici M, Haskins JR et al.: Improving high-content-screening assay performance by using division-arrested cells. Assay Drug Dev Technol 2005, 3: 515-523.

Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, Lazo JS: The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1. J Biol Chem 2005, 280: 19078-19086.

Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR et al.: AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer. Cancer Res 2005, 65: 4389-4400.

2004

Abraham VC, Taylor DL, Haskins JR (Eds):High content screening applied to large-scale cell biology. In Trends Biotechnol 2004, 22: 15-22.

Bhawe KM, Blake RA, Clary DO, Flanagan PM: An Automated Image Capture and Quantitation Approach to Identify Proteins Affecting Tumor Cell Proliferation. J Biomol Screen 2004, 9: 216-222.

Brisson M, Nguyen T, Vogt A, Yalowich J, Giorgianni A, Tobi D et al.: Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase. Mol Pharmacol 2004, 66: 824-833.

Chang KH, Zandstra PW: Quantitative screening of embryonic stem cell differentiation: endoderm formation as a model. Biotechnol Bioeng 2004, 88: 287-298.

Falsig J, Porzgen P, Lotharius J, Leist M: Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-1347. J Immunol 2004, 173: 2762-2770.

Fredericks ZL, Forte C, Capuano IV, Zhou H, Vanden Bos T, Carter P: Identification of potent human anti-IL-1RI antagonist antibodies. Protein Eng Des Sel 2004, 17: 95-106.

Giuliano KA, Chen YT, Taylor DL: High-Content Screening with siRNA Optimizes a Cell Biological Approach to Drug Discovery: Defining the Role of P53 Activation in the Cellular Response to Anticancer Drugs. J Biomol Screen 2004, 9: 557-568.

Gasparri F, Mariani M, Sola F, Galvani A: Quantification of the Proliferation Index of Human Dermal Fibroblast Cultures with the ArrayScanTM High-Content Screening Reader. J Biomol Screen 2004, 9: 232-243.

Lovborg H, Nygren P, Larsson R: Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and the cyanoguanidine CHS 828. Mol Cancer Ther 2004, 3: 521-526.

Mastyugin V, McWhinnie E, Labow M, Buxton F: A Quantitative High-Throughput Endothelial Cell Migration Assay. J Biomol Screen 2004, 9: 712-718.

Nam JS, Ino Y, Kanai Y, Sakamoto M, Hirohashi S: 5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin Exp Metastasis 2004, 21: 49-56.

Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M et al.: Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis. Science 2004, 306: 120-124.

Richards GR, Millard RM, Leveridge M, Kerby J, Simpson PB: Quantitative assays of chemotaxis and chemokinesis for human neural cells. Assay Drug Dev Technol 2004, 2: 465-472.

Schlag BD, Lou Z, Fennell M, Dunlop J: Ligand Dependency of 5-Hydroxytryptamine 2C Receptor Internalization. J Pharmacol Exp Ther 2004, 310: 865-870.

Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A et al.: Dysadherin Expression Facilitates Cell Motility and Metastatic Potential of Human Pancreatic Cancer Cells. Cancer Res 2004, 64: 6989-6995.

Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K et al.: a2HS-glycoprotein, an Antagonist of Transforming Growth Factor b In vivo, Inhibits Intestinal Tumor Progression. Cancer Res 2004, 64: 6402-6409.

Vakkila J, DeMarco R, Lotze M: Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level. J Immunol Methods 2004, 294: 123-134.

Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN et al.: Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Mol Cell Biol 2004, 24: 8374-8385.

Vogt A, Kalb EN, Lazo JS: A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity. Oncol Res 2004, 14: 305-314.

2003

Dahl JP, Wang-Dunlop J, Gonzales C, Goad MEP, Mark RJ, Kwak SP: Characterization of the WAVE1 Knock-Out Mouse: Implications for CNS Development. J Neurosci 2003, 23: 3343-3352.

Giuliano KA, Haskins JR, Taylor DL (Eds):Advances in high content screening for drug discovery. In Assay & Drug Development Technologies 2003, 1: 565-577.

Giuliano KA: High-Content Profiling of Drug-Drug Interactions: Cellular Targets Involved in the Modulation of Microtubule Drug Action by the Antifungal Ketoconazole. J Biomol Screen 2003, 8: 125-135.

Gullbo J, Wallinder C, Tullberg M, Lovborg H, Ehrsson H, Lewensohn R et al.: Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2. Mol Cancer Ther 2003, 2: 1331-1339.

Gururaja T, Li W, Catalano S, Bogenberger J, Zheng J, Keller B et al.: Cellular interacting proteins of functional screen-derived antiproliferative and cytotoxic peptides discovered using shotgun peptide sequencing. Chem Biol 2003, 10: 927-937.

Li Z, Yan Y, Powers EA, Ying X, Janjua K, Garyantes T et al.: Identification of Gap Junction Blockers Using Automated Fluorescence Microscopy Imaging. J Biomol Screen 2003, 8: 489-499.

Vogt A, Cooley KA, Brisson M, Tarpley MG, Wipf P, Lazo JS: Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem Biol 2003, 10: 733-742.

2002

Kapur R (Eds):Fluorescence imaging and engineered biosensors: functional and activity-based sensing using high content screening. In Ann N Y Acad Sci 2002, 961: 196-197.

Minguez JM, Giuliano KA, Balachandran R, Madiraju C, Curran DP, Day BW: Synthesis and High Content Cell-based Profiling of Simplified Analogues of the Microtubule Stabilizer (+)-Discodermolide. Mol Cancer Ther 2002, 1: 1305-1313.

Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J et al.: Interleukins 19, 20, and 24 Signal through Two Distinct Receptor Complexes. Differences in Receptor-Ligand Interactions Mediate Unique Biological Functions. J Biol Chem 2002, 277: 47517-47523.

Vogt A, Pestell KE, Day BW, Lazo JS, Wipf P: The Antisignaling Agent SC-aad9, 4-(Benzyl-(2-[(2,5-diphenyloxazole- 4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric Acid, Is a Structurally Unique Phospholipid Analogue with Phospholipase C Inhibitory Activity. Mol Cancer Ther 2002, 1: 885-892.

2001

Haskins JR, Rowse P, Rahbari R, de la Iglesia FA: Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes. Arch Toxicol 2001, 75: 425-438.

Simpson PB, Bacha JI, Palfreyman EL, Woollacott AJ, McKernan RM, Kerby J: Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis. Anal Biochem 2001, 298: 163-169.

Vogt A, Adachi T, Ducruet AP, Chesebrough J, Nemoto K, Carr BI et al.: Spatial Analysis of Key Signaling Proteins by High-content Solid-phase Cytometry in Hep3B Cells Treated with an Inhibitor of Cdc25 Dual-specificity Phosphatases. J Biol Chem 2001, 276: 20544-20550.

2000

Ghosh RN, Chen YT, DeBiasio R, DeBiasio RL, Conway BR, Minor LK et al.: Cell-based, high-content screen for receptor internalization, recycling and intracellular trafficking. Biotechniques 2000, 29: 170-175.

1999

Conway BR, Minor LK, Xu JZ, Gunnet JW, DeBiasio R, D'Andrea MR et al.: Quantification of G-Protein Coupled Receptor Internalization Using G-Protein Coupled Receptor-Green Fluorescent Protein Conjugates with the ArrayScanTM High-Content Screening System. J Biomol Screen 1999, 4: 75-86.

1998

Ding GJ, Fischer PA, Boltz RC, Schmidt JA, Colaianne JJ, Gough A et al.: Characterization and Quantitation of NF-kappa B Nuclear Translocation Induced by Interleukin-1 and Tumor Necrosis Factor-alpha . Development and Use of a High Capacity Fluoresence Cytometric System. J Biol Chem 1998, 273: 28897-28905.

1997

Giuliano KA, DeBiasio RL, Dunlay RT, Gough A, Volosky JM, Zock J et al.: High-Content Screening: A New Approach to Easing Key Bottlenecks in the Drug Discovery Process. J Biomol Screen 1997, 2: 249-259.